How to check for existing mail accounts?

Johnny Stork lists at
Fri Mar 28 21:29:55 GMT 2008

I have noticed a large increase in the amount of spam coming in to MS 
(latest) running on CentOS 5 and many are coming into non-existent email 
accounts. Is there a check that can be done for the existence of an 
account first, and then if non-existent, block even before any scanning 
is done, let alone processing through MS.

Thanks for any suggestions that anyone can give

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